In our recent study, published in “Cell Host & Microbe,” our research group studied the effect of foods on the microbiome. We recruited 34 volunteers and asked them to record everything they ate during a 17-day period and to also provide daily stool samples. By analyzing the microbial DNA in the stool samples, we were able to see what species made up their microbiome.
We found that the nutritional content of our subjects’ diets – the macro- and micronutrients like what is usually shown on a food label, such as fats, carbohydrates and sodium – didn’t help us to understand the microbial communities or how they changed from day to day.
But, when we considered the specific foods they ate, we could connect our subjects’ dietary intake to their microbiome composition. We think that this worked because our method let us use the concept of a food to capture some of the complexity of the compounds inside that food that are not usually listed on a food label.
We believe it is noteworthy that the the effects of foods were very personalized meaning that we saw the same species of microbes respond differently to similar foods in different people.
I am hopeful that in the near future we will be able to confidently tell you what foods will change your microbiome. As a whole, microbiome science is not able to confidently do that just yet, but our recent study contributes towards that long-term goal.