Bezos, who became the world's richest person as Amazon's stock soared, said in another note to staff that Wilke's "legacy and impact will live on long after he departs."
Wilke joined Amazon as vice president in 1999 when the young company still sent corporate workers to help pack orders during the holiday shopping season. Now, he oversees a range of businesses including online and physical stores and the loyalty club Prime, which helped make Amazon the world's largest internet retailer.
Wilke said in his note that he does not have a new job and is "as happy with and proud of Amazon as ever," but he wants to move on and step aside for others.
Clark, who will take over, currently is Amazon's senior vice president of worldwide operations. He built out the company's air cargo fleet and last-mile service that now delivers more packages for Amazon than any other U.S. carrier.
The company last month posted its biggest profit ever, as sales surged during the Covid-19 pandemic.
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