Zydus Group chairperson Pankaj Patel said that company is optimistic of the phase III clinical trial outcomes as well. "We would be able to start production of the novel vaccine on its successful completion," he said.
The DNA platform used in ZyCoV-D improves the vaccine’s stability, lowering cold chain requirements and making it usable in remotest regions of the country. Administered through the intradermal route, it also allows for the ease of administration.
Further, the platform also provides ease of manufacturing the vaccine with minimal biosafety requirements (BSL-1). The platform can be used to modify the vaccine in couple of weeks in case the virus mutates to ensure that the vaccine still elicits protection.
The plasmid DNA when introduced into the host cells would be translated into the viral protein and will elicit a strong immune response mediated by the cellular and humoral arms of the human immune system, which play a vital role in protection from disease as well as viral clearance. National Biopharma Mission, BIRAC, Department of Biotechnology, ICMR and NIV Pune have also supported the development of ZyCoV-D, the company acknowledged.
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