They contained echoes of the harsh rhetoric of the past.
"Any strategy that seeks to destroy the revolution either through coercion or pressure or through more subtle methods will fail," Cuba's president told legislators.
He also rejected any "lessons" on human rights from the US, saying his country "has a lot to be proud about" on the issue.
Surrounded by Cuban-American exiles and Cuban dissidents in Miami, Trump announced last month that the US would impose new limits on US travellers to the island and ban any payments to the military-linked conglomerate that controls much of the island's tourism industry.
He said the US would consider lifting those and other restrictions only after Cuba returned fugitives and made a series of other internal changes including freeing political prisoners, allowing freedom of assembly and holding free elections.
Trump's policy retained elements of Obama's reforms but tightened restrictions on travel and employed harsh rhetoric on human rights.
On Friday in Washington, the Trump administration said it was suspending for another six months a provision of the US embargo on Cuba.
The State Department said it told Congress that it will keep suspending a provision of the Helms-Burton Act that deals with property seized from Americans. The provision lets Americans use US courts to sue non-American companies that operate and deal with property confiscated after Fidel Castro's revolution.
Speaking to the National Assembly, Castro called the Trump administration's policies a "setback," though he reiterated his government's position that it would work to normalize relations with Washington.
Earlier in the legislative session, Economy Minister Ricardo Cabrisas announced that Cuba's economy is growing again after a dip last year.
Cabrisas said the economy grew around 1 percent in the first half of 2017. That puts GDP growth on track to hit 2 percent for the year.
The government said the economy shrank last year by 1 per cent amid falling support from troubled Venezuela. That was the first decrease reported in two decades. Cabrisas said that instability in the supply of Venezuelan oil weighs on the country but tourism, construction, transportation and communications were growing.
Foreign media did not have access to the National Assembly session.
Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.
As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.
Support quality journalism and subscribe to Business Standard.