Tech heavyweights from Google-parent Alphabet to Apple and Amazon also suffered but have still mushroomed hugely in value this year.
"Even if a vaccine proves effective, inoculating a large enough part of the population will take time and leave these segments prone to economic lockdown fallout," said Commerzbank analyst Christoph Rieger.
The shakiness of moves may have reflected both those doubts about the speed at which a vaccine can be produced and distributed as well as the remaining doubts about whether it will work as a solution in the long-run.
But there is also the conviction that the pandemic has fundamentally changed business for many of these companies in ways that will not be reversed.
"Investors are now focused on how the 'new normal' looks ... and how sustainable are the tailwinds for such companies as the direct impact of the pandemic on consumer behavior starts to diminish," MKM Partners analyst Rohit Kulkarni, said.
Peloton, which has seen demand for its at-home fitness systems soar due to gym closures, recently posted a 274% jump in quarterly profit for its unit which sells interactive fitness equipment.
An outstanding beneficiary among tech stocks from the shift to work from home is Zoom, whose shares have jumped over 460% this year as corporate firms, schools, and organizations run countless virtual meetings on its video conferencing app.
Amazon.com Inc and Microsoft Corp have seen a substantial boost to their business but the capital they have available for new investment has soared as a result - potentially giving them more leverage going forward.
Shares of video game and e-sports related companies, which benefited from long cancellations of traditional sports leagues, tumbled after Pfizer's announcement, with game studios such as Activision Blizzard and Take-Two Interactive Software ending Monday's session lower.
Gaming peripheral makers such as Turtle Beach and Corsair Gaming also tumbled on Monday, while U.S. listed shares of game developers and e-sports organizers Bilibili Inc and Sea Limited saw their worst day since March.
All, however, are still up between 50% and 350% since March, while Corsair has risen 57% since its initial public offering in September.
"The market is likely discounting a deceleration of growth for the sector in 2021," said Will Hershey, CEO of Roundhill Investments.
"However, I believe that the growth in gaming due to the pandemic likely increased the trajectory of gaming adoption for years to come."
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