She died Tuesday of a "cardiac event," The New York Times reported, citing her publicist.
Willis, who penned "I'll Be There For You" -- the theme for the long-running show "Friends" -- as well as several hits by Earth, Wind and Fire, was inducted into the Songwriters Hall of Fame in 2018.
She won a Grammy in 1985 for her work on the soundtrack for "Beverly Hills Cop," and was nominated for another two decades later for "The Color Purple," according to the Recording Academy's website.
Willis did not know how to play music, but learned to become a songwriter by listening to rhythms coming through the walls of Motown studios in Detroit, the city in which she grew up, according to the Times.
"I, very thankfully, have a few songs that will not go away," Willis told the newspaper.
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