The pair had been the standout performers in Thursday's opener and came to the rescue here, Billings finishing on 46 not out while Willey followed up his 2-48 with an unbeaten 47 in the evening sunshine.
Earlier, Ireland overcame another poor start after winning the toss and being reduced to 91-6 before Curtis Campher led the recovery. Campher, in only his second ODI, scored an 87-ball 68 with eight fours before being dismissed by seamer Saqib Mahmood (2-45).
Campher shared two key partnerships late in the innings a seventh-wicket 60-run stand with Simi Singh (25) and 56 runs for the eighth wicket with Andy McBrine (24).
Players again took a knee to support Black Lives Matter before the game.
The third ODI is on Tuesday.
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